abstract：:Adolescent girls with a history of premature pubarche have an increased incidence of functional ovarian hyperandrogenism [a form of polycystic ovary syndrome (PCOS)] at adolescence, which is usually associated with hyperinsulinemia and dyslipemia. The hyperinsulinemia and lipid disturbances can often be detected in th...

journal_title：Journal of endocrinological investigation

authors： Ibáñez L,de Zegher F,Potau N

更新日期：1998-10-01 00:00:00

abstract：:Hexarelin (Hex) is a synthetic hexapeptide with potent GH-releasing activity in both animals and men. Aim of this study was to evaluate the GH response to a maximal dose of Hex and GH-releasing hormone (GHRH) in a group of patients with Prader-Willi syndrome (PWS). Seven patients (4 boys and 3 girls, age 2.4-14.2 yr) ...

journal_title：Journal of endocrinological investigation

authors： Cappa M,Raguso G,Palmiotto T,Faedda A,Gurreri F,Neri G,Deghenghi R,Loche S

更新日期：1998-09-01 00:00:00

abstract：:Aging is related to critical changes of the hypothalamo-pituitary-adrenal function. A decline in serum DHEA levels has been demonstrated in healthy elderly subjects, while ACTH and cortisol concentrations remain at normal values. The purpose of the present study was to investigate the effect of aging on pituitary-adre...

journal_title：Journal of endocrinological investigation

authors： Luisi S,Tonetti A,Bernardi F,Casarosa E,Florio P,Monteleone P,Gemignani R,Petraglia F,Luisi M,Genazzani AR

更新日期：1998-07-01 00:00:00

abstract：:Not only thyroid adenomas and carcinomas, but also the majority of single and well delimited goiter nodules, even if morphologically heterogeneous, are of clonal origin. However, it is still unknown whether the nodules of rapidly growing, recurrent goiters are clonal or polyclonal. We investigated by PCR-based analysi...

journal_title：Journal of endocrinological investigation

authors： Harrer P,Broecker M,Zint A,Schatz H,Zumtobel V,Derwahl M

更新日期：1998-06-01 00:00:00

abstract：:Dopamine in humans inhibits the secretion of luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH) and prolactin (PRL), and is a stimulator of growth hormone (GH) secretion. Dopamine-D1 receptor stimulation with fenoldopam increases basal PRL levels, suppresses TSH, and incr...

journal_title：Journal of endocrinological investigation

authors： Grodum E,Andersen M,Hangaard J,Koldkjaer O,Hagen C

更新日期：1998-05-01 00:00:00

abstract：:Typical modifications of cardiovascular activity and water and salt homeostasis throughout female reproductive life are well known. Differences in plasma levels of calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) have been observed in conditions characterized by different estrogenic levels, ...

journal_title：Journal of endocrinological investigation

authors： Bernardi F,Valentini A,Margutti A,Santuz M,Degli Uberti EC,Petraglia F,Genazzani AR

更新日期：1998-04-01 00:00:00

abstract：:To analyze the inhibitory effect of hormone replacement therapy (HRT) on bone resorption, we measured urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type I collagen as new markers of bone resorption and assessed their correlation with bone mineral density, in comparison with urinary pyridinoline (...

journal_title：Journal of endocrinological investigation

authors： Taga M,Uemura T,Minaguchi H

更新日期：1998-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) combined with fractures of long bones or large joints is often associated with enhanced osteogenesis (early fracture healing accompanied by hypertrophic callus formation and/or heterotopic ossifications). Humoral factors that cause enhanced osteogenesis in patients with TBI are not yet ide...

journal_title：Journal of endocrinological investigation

authors： Wildburger R,Zarkovic N,Tonkovic G,Skoric T,Frech S,Hartleb M,Loncaric I,Zarkovic K

更新日期：1998-02-01 00:00:00

abstract：:Juvenile Rheumatoid Arthritis (JRA) is frequently associated with osteoporosis. In order to determine if JRA osteoporosis is related to reduced formation or to increased bone resorption or both, serum levels of calcium (Ca), phosphorus (PO4), magnesium (Mg), alkaline phosphatase (ALP), parathormone (PTHi), 25-hydroxyv...

journal_title：Journal of endocrinological investigation

authors： Falcini F,Ermini M,Bagnoli F

更新日期：1998-01-01 00:00:00

abstract：:A 34-yr-old nulliparous black woman presented with hair loss, facial hirsutism, irregular menses and infertility associated with greatly increased serum total testosterone levels. The adrenal glands and the ovaries were normal on radiological and ultrasonographic investigation. Catheterization of the veins draining fr...

journal_title：Journal of endocrinological investigation

authors： Marcondes JA,Nery M,Mendonça BB,Hayashida SA,Halbe HW,Carvalho FM,Wajchenberg BL

更新日期：1997-12-01 00:00:00

abstract：:In obesity there is a clear reduction of both spontaneous and stimulated GH secretion. Furthermore, in obese patients the somatotrope responsiveness to provocative stimulation is selectively refractory to the inhibitory effect of glucose load. It has been hypothesized that hyperinsulinism of obese patients could play ...

journal_title：Journal of endocrinological investigation

authors： Limone P,Oleandri SE,Ajmone Catt P,Grottoli S,Frangioni C,Avogadri E,Perrin M,Valetto MR,Maccario M

更新日期：1997-11-01 00:00:00

abstract：:Several cases of sporadic primary hyperparathyroidism in association with fibrous dysplasia of the bone have been reported in the English literature. Since fibrous dysplasia is a major feature and hyperparathyroidism is occasionally found in the McCune-Albright syndrome, we hypothesized that such cases may represent a...

journal_title：Journal of endocrinological investigation

authors： Hammami MM,al-Zahrani A,Butt A,Vencer LJ,Hussain SS

更新日期：1997-10-01 00:00:00

abstract：:Erythrocytes glutathione (GSH) levels were measured in erythrocytes from 33 subjects, at baseline and after 2-hour glucose loading in order to investigate the effect of glucose ingestion on the erythrocyte GSH. According to the World Health Organisation criteria 18 subjects had normal glucose tolerance (NGT)(mean age ...

journal_title：Journal of endocrinological investigation

authors： Konukoğlu D,Hatemi H,Ozer EM,Gönen S,Akçay T

更新日期：1997-09-01 00:00:00

abstract：:Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...

journal_title：Journal of endocrinological investigation

authors： Pinilla L,Tena-Sempere M,Aguilar E

更新日期：1997-07-01 00:00:00

abstract：:We experienced an unusual combination of painless thyroiditis and Sheehan's syndrome in a single patient. A 29-year-old postpartum woman was referred to us for suspected Sheehan's syndrome. Endocrine tests confirmed the diagnosis, but, unexpectedly, her thyroid hormone levels in the plasma were elevated. Based on the ...

journal_title：Journal of endocrinological investigation

authors： Watanobe H,Kawabe H

更新日期：1997-06-01 00:00:00

abstract：:Prolactin (PRL) circulates as multiple molecular weight variants: glycosylated phosphorylated, deamidated and sulphated forms. The profiles of the forms, as determined by isoelectrofocusing (IEF), differ in physiological and pathological conditions. The case of a 72-year-old woman affected by an invasive prolactinoma ...

journal_title：Journal of endocrinological investigation

authors： Guido R,Valenti S,Foppiani L,De Martini D,Cossu M,Giusti M

更新日期：1997-05-01 00:00:00

abstract：:Our aim was to investigate the effect of GnRH-agonist (GnRH-a) induced suppression of plasma sex steroids on serum GH, insulin like growth factor-I (IGF-I) and insulin levels after an oral glucose load (OGTT) in women with polycystic ovary syndrome (PCOS). Serum insulin, GH and IGF-I levels during a 75-g 4-h OGTT were...

journal_title：Journal of endocrinological investigation

authors： Tropeano G,Liberale I,Vuolo IP,Barini A,Caroli G,Carfagna P,Menini E

更新日期：1997-04-01 00:00:00

abstract：:3 alpha-androstanediol glucuronide (3 alpha diolG) is a marker of peripheral tissue androgen metabolism. There are no previous data regarding complete paediatric reference ranges for 3 alpha diolG. In order to obtain reference values for 3 alpha diolG we have measured serum levels of 3 alpha diolG in 283 healthy child...

journal_title：Journal of endocrinological investigation

authors： Rittner HL,Lee PD,Blum WF,Doerr HG,Steiss J,Kreuder J,Rascher W,Kiess W

更新日期：1997-03-01 00:00:00

abstract：:Antithyroid hormone autoantibodies (THBA), described in both humans and animals, result in variable interference when thyroid hormone plasma levels are measured by immunoassays. We previously described a quick chromatographic method to detect circulating THBA in humans. In the present experience, we applied the method...

journal_title：Journal of endocrinological investigation

authors： Savastano S,Tommaselli AP,Valentino R,Dorato M,Scarpitta MT,Persechino A,Ciaramella P,Lombardi G

更新日期：1996-12-01 00:00:00

abstract：:Thyroid-stimulating antibody (TSAb) activity and the TSH-binding inhibitory immunoglobulin (TBII) index were assessed in 158 patients with Graves' disease who had been treated with 131I 6-14 years earlier. Twenty-one patients (13%) were still hyperthyroid, 45 (28%) were euthyroid, 44 (28%) were subclinically hypothyro...

journal_title：Journal of endocrinological investigation

authors： Yoshida K,Aizawa Y,Kaise N,Fukazawa H,Kiso Y,Sayama N,Mori K,Hori H,Abe K

更新日期：1996-11-01 00:00:00

abstract：:To characterize natriuretic peptide receptor (NPr) gene expression in human tissues, we cloned portions of the cDNAs codifying for NPr with guanylyl cyclase activity (NPr-A and NPr-B) and without guanylyl cyclase activity (NPr-C). Total RNA was extracted from samples taken at surgery from normal human tissues. NPr-A a...

journal_title：Journal of endocrinological investigation

authors： Sarzani R,Dessì-Fulgheri P,Paci VM,Espinosa E,Rappelli A

更新日期：1996-10-01 00:00:00

abstract：:A longitudinal study was carried out in an area of endemic goiter of north-eastern Sicily. Three different surveys (in 1977, 1983 and 1994) evaluated the epidemiological prevalence of goiter in schoolchildren of the endemic area (towns of Bronte, Troina and Maniaci) in comparison to an iodine sufficient control area (...

journal_title：Journal of endocrinological investigation

authors： Regalbuto C,Squatrito S,La Rosa GL,Cercabene G,Ippolito A,Tita P,Salamone S,Vigneri R

更新日期：1996-10-01 00:00:00

abstract：:To determine whether G proteins are involved in the regulation of mouse placental lactogen-I (mPL-I) and/or mPL-II secretion before midpregnancy, mouse placental tissue from day 7 of pregnancy was dispersed with collagenase, cells were fractionated on a percoll gradient, and the purified trophoblast cells were culture...

journal_title：Journal of endocrinological investigation

authors： Yamaguchi M,Miyake A

更新日期：1996-09-01 00:00:00

abstract：:A strong relationship was previously described between the nocturnal oscillations of plasma renin activity (PRA) and the sleep cycles, with levels of PRA that increase during non rapid eye movement sleep and decrease during rapid eye movement sleep. This study was designed to determine whether ritanserin, a 5-hydroxyt...

journal_title：Journal of endocrinological investigation

authors： Brandenberger G,Luthringer R,Muller G,Gronfier C,Schaltenbrand N,Macher JP,Muzet A,Follenius M

更新日期：1996-09-01 00:00:00

abstract：:Volume receptors are situated in many organs and are capable of modulating ADH secretion. We have evaluated the variation of plasma ADH concentration after an experimentally induced increase of cerebrospinal fluid (CSF) pressure (PCSF). The experiment was performed in controlled environmental conditions to avoid pain ...

journal_title：Journal of endocrinological investigation

authors： Satta A,Palomba D,Demontis MP,Varoni MV,Faedda R,Ginanni A,Anania V

更新日期：1996-07-01 00:00:00

abstract：:The activities of total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzymes were measured in cancerous and non-cancerous adjacent tissues from 15 patients with follicular thyroid cancer containing single nodule. SOD and GSH-Px activities were found lower but malondialdehyde levels hi...

journal_title：Journal of endocrinological investigation

authors： Durak I,Bayram F,Kavutcu M,Canbolat O,Oztürk HS

更新日期：1996-05-01 00:00:00

abstract：:Formation of connective tissue is an essential step in the process of wound healing. After menopause an atrophy of connective tissues in skin, bone, and reproductive organs takes place. Using a dead-space wound healing model we measured collagen synthesis and deposition, and cell replication in the granulation tissue ...

journal_title：Journal of endocrinological investigation

authors： Gniadecki R,Wyrwas B,Kabala A,Matecka J

更新日期：1996-04-01 00:00:00

abstract：:Aim of the study was to compare urinary galactosyl-hydroxylysine (GHyl), deoxypyridinoline (D-Pyr) and pyridinoline (Pyr) before and after 5 to 9 months of hormone replacement therapy (HRT) in postmenopausal women. The urinary markers were measured by HPLC in the second void of fasting samples and were expressed as ra...

journal_title：Journal of endocrinological investigation

authors： Marabini R,Sirtori P,Chionna R,Barzizza L,Rubinacci A

更新日期：1996-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced inflammatory stress activates the hypothalamus-pituitary-adrenal (HPA) function. Interleukin-I (IL-1) is one of the key factors during this event; however, the mechanisms mediating IL-1 stimulation of HPA axis are still unclear. The present study evaluated the possible involvement of g...

journal_title：Journal of endocrinological investigation

authors： Guo AL,Petraglia F,Nappi RE,Criscuolo M,Ficarra G,Salvestroni C,Genazzani AD,Trentini GP,Genazzani AR

更新日期：1996-02-01 00:00:00

abstract：:As it has been hypothesized that IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the insulin-like growth factors (IGFs) in the ovary, we studied the production of the IGFBPs by human granulosa cells (GC) in culture and the role of IGFBP-3 in the modulatio...

journal_title：Journal of endocrinological investigation

authors： Barreca A,Artini PG,Cesarone A,Arvigo M,D'Ambrogio G,Genazzani AR,Giordano G,Minuto F

更新日期：1996-01-01 00:00:00

abstract：:We report the case of a patient who developed Graves' disease and a papillary thyroid cancer only 5 years after irradiation and adjuvant chemotherapy for Hodgkin's disease. This case is peculiar for the very short latency time between Hodgkin's disease treatment and thyroid cancer development, an event possibly relate...

journal_title：Journal of endocrinological investigation

authors： Belfiore A,Pellegriti G,Milone G,Vigneri G,Gangemi P,Fiumara A,Vigneri R

更新日期：1995-12-01 00:00:00

abstract：:Two radioimmunological techniques for the measurement of anti-alpha-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves' disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inh...

journal_title：Journal of endocrinological investigation

authors： Winand RJ,Winand-Devigne J,Cox C,Caulier C,Meurisse M

更新日期：1995-11-01 00:00:00

abstract：:The occurrence of tumors originating from aberrant adrenocortical tissue in ectopic site is very rare. Up to now only two cases of ectopic aldosterone-producing adenoma have been described. We have observed another case of ectopic aldosteronoma, located in the retrocaval region, laterally to the body of the 12th thora...

journal_title：Journal of endocrinological investigation

authors： Mazza E,Papotti M,Durando R,Robecchi A,Camanni F

更新日期：1995-11-01 00:00:00

abstract：:Patients with Cushing syndrome have elevated 24 h urinary free cortisol excretion and loss of diurnal rhythm of plasma cortisol, however, morning total plasma cortisol concentrations are often similar to those of normal individuals. To test the hypothesis that an elevated morning plasma free cortisol could distinguish...

journal_title：Journal of endocrinological investigation

authors： Friedman TC,Yanovski JA

更新日期：1995-10-01 00:00:00

abstract：:Cardiovascular problems have long been recognized as responsible for an increased morbidity and mortality in patients with acromegaly. The aim of the present study was to evaluate echocardiographically the prevalence of cardiomyopathy in a cohort of acromegalic patients and to analyze the results in relation to demogr...

journal_title：Journal of endocrinological investigation

authors： Terzolo M,Avonto L,Matrella C,Pozzi R,Luceri S,Borretta G,Pecchio F,Ugliengo G,Magro GP,Reimondo G

更新日期：1995-09-01 00:00:00

abstract：:Apparent mineralocorticoid excess (AME) is a syndrome attributable to congenital deficiency of the enzyme 11 beta-dehydrogenase (11 beta-OHSD) which converts active glucocorticoid cortisol to inactive cortisone. When 11 beta-OHSD activity is impaired, cortisol acts as a potent mineralocorticoid and causes hypertension...

journal_title：Journal of endocrinological investigation

authors： Shimojo M,Stewart PM

更新日期：1995-07-01 00:00:00

abstract：:Following presentation and diagnosis, microprolactinomas usually follow a benign course and rarely progress to macroprolactinomas. However, clinically significant enlargement of prolactinomas during pregnancy, presumably related to estrogen stimulation, has been reported. This report describes a patient with amenorrhe...

journal_title：Journal of endocrinological investigation

authors： Garcia MM,Kapcala LP

更新日期：1995-06-01 00:00:00

abstract：:An immunohistochemical study with two rabbit polyclonal antibodies I-AR76 and CA-08-351 against Endothelin-1 (ET-1) was performed in 133 human thyroid specimens: 5 normal thyroids, 30 multinodular goiters (15 toxic and 15 nontoxic), 20 Graves' diseases, 5 Hashimoto's thyroiditis, 26 adenomas (6 Hürthle cell, 16 toxic ...

journal_title：Journal of endocrinological investigation

authors： Lenziardi M,Viacava P,Fiorini I,Castagna M,Nardini V,Pollina L,De Negri F,Goletti O,Di Coscio G,Bevilacqua G

更新日期：1995-05-01 00:00:00

abstract：:We report the case of a 17-year-old girl presenting short stature (height 149 cm, below the 3rd percentile), obesity (weight 83.5 kg, body mass index 37 kg/m2) and secondary amenorrhea, in whom endocrinological evaluation disclosed an absolute lack of GH responsiveness to both suprapituitary challenges and repetitive ...

journal_title：Journal of endocrinological investigation

authors： Scacchi M,Alé G,Silvestri P,Cavagnini F

更新日期：1995-05-01 00:00:00

abstract：:Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor. We, therefore, re-evalu...

journal_title：Journal of endocrinological investigation

authors： Nagayama Y,Yamasaki H,Takeshita A,Kimura H,Ashizawa K,Yokoyama N,Yamashita S,Rapoport B,Nagataki S

更新日期：1995-04-01 00:00:00